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Within our examine, we have been in a position to considerably escalate the dose of CX-5461 further than that achieved in the 1st-in-human review in individuals with hematologic cancers. The RP2D of 475 mg/m2 on times 1, eight, and 15 of the 4-7 days cycle, was depending on phototoxicity, which happened despite demanding UV mild avoidance protoco